Description
DIVAA™Angioreactorsare onecentimeterlongcylindersthatissealedononeendandhouses20μltotalvolume.Theyare madeofimplant-gradesiliconeandprovidedsterile.AngioreactorsarefilledwithTrevigen’sPathClear®basementmembraneextract(BME)*premixedwithorwithoutangiogenic-modulatingfactorsand implantedsubcutaneouslyinthedorsalflankofnudemice. Throughtheprocessofangiogenesis,hostvascularendothelialcellsproceedtoinvadeandgrowintotheBME,formingvesselsintheangioreactor. ThesleekdesignoftheangioreactorprovidesastandardizedplatformforreproducIBLeandquantifiableinvivoangiogenesisassays.Comparedtotheplugassay,theangioreactorpreventsassayerrorsduetoabsorptionofthebasementmembraneextractbythemouse.Inaddition,theangioreactorusesonlyafractionofthematerialsconservingbothBMEandtestcompoundsused,anduptofourangioreactorsmaybeimplantedineachmouse,allowingforgreaterstatisticalpower. Theseareanessentialcomponentof theDirectedInVivoAngiogenesisAssays(DIVAA™).
*ThePathClear®designationmeans:
- Nobacterialorfungalgrowthdetectedafterincubationat37°Cfor14daysfollowingUSPXXIVChapter71sterilitytest.
- NegativebyPCRtestfor:mycoplasma,17bacterialandvirusstrainstypicallyincludedinmouseantibodyproduction(MAP)testing,plus13additionalmurineinfectiousagentsincludingLDEV,foratotalof31organismsandviruses.
| Catalog#3450-048-DAincludes: | ||
| CatalogNumber | Description | Qty |
| 3450-048-02 | DIVAABME | 1 |
| 3450-048-01 | DIVAAAngioreactor | 1 |
