Description

FEATURES:

• Speciallytreatedslidestopromoteagaroseadherence
• Readytouselowmeltagarose(LMAgarose)inconvenientsize
• LysisSolutionsuitableforeitheralkalineorneutralcometassay
• Optimizedelectrophoresisconditions

APPLICATIONS:

• Applicablefortheanalysisofeithersingle-ordouble-strandDNAbreaks
• StudycellularresponsestoDNAdamage
• ScreenforinhibitorsofDNArepair
• Testchemicalsfortoxicity
• Screenforenvironmentalmutagens

USP1targetingimpedesGBMgrowthbyinhibitingstemcell
Jin-KuLee,NakhoChang,YeupYoon,HeekyoungYang,HeejinCho,EunheeKim,YongjaeShin,WonyoungKang,YoungTaekOh,GyeongInMun,KyeungMinJoo,Do-HyunNam,andJeongwuLee
NeuroOncology,Jan2016;18:37–47.
http://neuro-oncology.oxfordjournals.org/cgi/content/abstract/18/1/37

DNAdouble-strandbreakrepair:atheoreticalframeworkanditsapplication
PhilipJ.Murray,BartCornelissen,KatherineA.Vallis,andS.JonChapman
JRSocInterface,Jan2016;13:20150679.
http://rsif.royalsocietypublishing.org/cgi/content/abstract/13/114/20150679

TheOpposingActionsofArABIdopsisCHROMOSOMETRANSMISSIONFIDELITY7andWINGSAPART-LIKE1and2DifferinMitoticandMeioticCells
KuntalDe,PabloBolaños-Villegas,SayantanMitra,XiaohuiYang,GarretHoman,Guang-YuhJauh,andChristopherA.Makaroff
PLANTCELL,Feb2016;28:521–536
http://www.plantcell.org/cgi/content/abstract/28/2/521

“Intracellularaccumulationofindiumionsreleasedfromnanoparticlesinducesoxidativestress,proinflammatoryresponseandDNAdamage”
YosukeTabei,AkinariSonoda,YoshihiroNakajima,VasudevanpillaiBiju,YojiMakita,YasukazuYoshida,andMasanoriHorie
J.Biochem.,Feb2016;159:225–237
http://jb.oxfordjournals.org/cgi/content/abstract/159/2/225

“Long-termexposuretodieselengineexhaustinducesprimaryDNAdamage:apopulation-basedstudy”
HuaweiDuan,XiaoweiJia,QingfengZhai,LuMa,ShanWang,ChuanfengHuang,HaishengWang,YongNiu,XueLi,YufeiDai,ShanfaYu,WeiminGao,WenChen,andYuxinZheng
Occup.Environ.Med.,Feb2016;73:83–90.
http://oem.bmj.com/cgi/content/abstract/73/2/83

LinkingCancerMetabolismtoDNARepairandAcceleratedSenescence
ElenaV.Efimova,SatoeTakahashi,NoumaanA.Shamsi,DingWu,EdwardineLabay,OlesyaA.Ulanovskaya,RalphR.Weichselbaum,SergeyA.Kozmin,andStephenJ.Kron
Mol.CancerRes.,Feb2016;14:173–184.
http://mcr.aacrjournals.org/cgi/content/abstract/14/2/173

DNA-PKtriggershistoneubiquitinationandsignalinginresponsetoDNAdouble-strandbreaksproducedduringtherepairoftranscriptionblockingtopoisomeraseIlesions
AgneseCristini,Joon-HyungPark,GiovanniCapranico,GaëlleLegube,GillesFavre,andOlivierSordet
NucleicAcidsRes.,Feb2016;44:1161–1178
http://nar.oxfordjournals.org/cgi/content/abstract/44/3/1161

RequirementforhumanMps1/TTKinoxidativeDNAdamagerepairandcellsurvivalthroughMDM2phosphorylation
Zheng-ChengYu,Yi-FuHuang,andSheau-YannShieh
NucleicAcidsRes.,Feb2016;44:1133–1150
http://nar.oxfordjournals.org/cgi/content/abstract/44/3/1133

CytokineoverproductionandcrosslinkerhypersensitivityareunlinkedinFanconianemiamacrophages
MichaelR.Garbati,LauraE.Hays,R.KeaneyRathbun,NathanielJillette,KathyChin,MuhsenAl-Dhalimy,AnupriyaAgarwal,AmyE.HanlonNewell,SusanB.Olson,andGroverC.Bagby,Jr.
J.Leukoc.Biol.,Mar2016;99:455–465
http://www.jleukbio.org/cgi/content/abstract/99/3/455

TheRoleofHMGB1inRADIoresistanceofBladderCancer
SanhitaShrivastava,JoseJoaoMansure,WaelAlmajed,FabioCury,GerardoFerbeyre,MarijaPopovic,JanSeuntjens,andWassimKassouf
Mol.CancerTher.,Mar2016;15:471–479
http://mct.aacrjournals.org/cgi/content/abstract/15/3/471

DifferencesinquantificationofDNAdouble-strandbreaksassessedby53BP1/H2AXfocusformationassaysandthecometassayinmammaliancellstreatedwithirradiationandN-acetyl-L-cysteine
TomomiKurashige,MikaShimamura,andYujiNagayama
JRadiatRes,Mar2016;10.1093/jrr/rrw001.
http://jrr.oxfordjournals.org/cgi/content/abstract/rrw001v1

SequentialCombinationTherapyofCDKInhibitionandDoxorubicinIsSyntheticallyLethalinp53-MutantTriple-NegativeBreastCancer
NatalieA.Jabbour-Leung,XianChen,TuyenBui,YufengJiang,DongYang,SmruthiVijayaraghavan,MarkJ.McArthur,KellyK.Hunt,andKhandanKeyomarsi
Mol.CancerTher.,Apr2016;15:593–607.
http://mct.aacrjournals.org/cgi/content/abstract/15/4/593

“miR-155OverexpressionPromotesGenomicInstabilitybyReducing
High-fidelityPolymeraseDeltaExpressionandActivatingError-ProneDSBRepair”
JenniferR.Czochor,ParkerSulkowski,andPeterM.Glazer
Mol.CancerRes.,Apr2016;14:363–373.
http://mcr.aacrjournals.org/cgi/content/abstract/14/4/363

“Apanelofinvitroteststoevaluategenotoxicandmorphological
neoplastictransformationpotentialonBalb/3T3cellsbypristineandremediatedtitaniaandzirconiananoparticles”
AndreaStoccoro,SebastianoDiBucchianico,ChiaraUboldi,FabioCoppedè,JessicaPonti,ClaudiaPlacidi,MagdaBlosi,SimonaOrtelli,AnnaLuisaCosta,andLuciaMigliore
Mutagenesis,Apr2016;10.1093/mutage/gew015
http://mutage.oxfordjournals.org/cgi/content/abstract/gew015v1

“UniqueepigeneticinfluenceofH2AXphosphorylationandH3K56
acetylationonnormalstemcellradioresponses”
“KeithM.Jacobs,SandeepMisri,BarbaraMeyer,SuyashRaj,CheriL.Zobel,BarryP.Sleckman,DennisE.Hallahan,andGirdharG.Sharma”
Mol.Biol.Cell,Apr2016;27:1332–1345
http://www.molbiolcell.org/cgi/content/abstract/27/8/1332

“AubiquitylationsiteinCockaynesyndromeBrequiredforrepairof
oxidativeDNAdamage,butnotfortranscription-couplednucleotideexcisionrepair”
MichaelRanes,StefanBoeing,YumingWang,FranziskaWienholz,HervéMenoni,JaneWalker,VeselaEncheva,ProbirChakravarty,Pierre-OlivierMari,AengusStewart,GiuseppinaGiglia-Mari,AmbrosiusP.Snijders,WimVermeulen,andJesperQ.Svejstrup
NucleicAcidsRes.,Apr2016;10.1093/nar/gkw216.
http://nar.oxfordjournals.org/cgi/content/abstract/gkw216v2

CharacterizingRequirementsforSmallUbiquitin-likeModifier(SUMO)ModificationandBindingonBaseExcisionRepairActivityofThymine-DNAGlycosylaseinVivo
DylanMcLaughlin,ChristopherT.Coey,Wei-ChihYang,AlexanderC.Drohat,andMichaelJ.Matunis
J.Biol.Chem.,Apr2016;291:9014–9024
http://www.jbc.org/cgi/content/abstract/291/17/9014

“LongnoncodingRNAPOU6F2-AS2isassociatedwithoesophageal
squamouscellcarcinoma”
JingLiu,XiangdongSun,HongchengZhu,QinQin,XiYang,andXinchenSun
J.Biochem.,Apr2016;10.1093/jb/mvw025.
http://jb.oxfordjournals.org/cgi/content/abstract/mvw025v2

“MethylationofhistoneH4lysine20byPR-Set7ensurestheintegrityoflatereplicatingsequencedomainsinDrosophila”
YulongLi,RobinL.Armstrong,RobertJ.Duronio,andDavidM.MacAlpine
NucleicAcidsRes.,Apr2016;10.1093/nar/gkw333
http://nar.oxfordjournals.org/cgi/content/abstract/gkw333v1