Description

FEATURES:

• Speciallytreatedslidestopromoteagaroseadherence
• Readytouselowmeltagarose(LMAgarose)inconvenientsize
• LysisSolutionsuitableforeitheralkalineorneutralcometassay
• Optimizedelectrophoresisconditions

APPLICATIONS:

• Applicablefortheanalysisofeithersingle-ordouble-strandDNAbreaks
• StudycellularresponsestoDNAdamage
• ScreenforinhibitorsofDNArepair
• Testchemicalsfortoxicity
• Screenforenvironmentalmutagens

“HT-COMET:anovelautomatedapproachforhighthroughput
assessmentofhumanspermchromatinquality”
OcéaneAlbert,WolfgangE.Reintsch,PeterChan,andBernardRobaire
Hum.Reprod.,May2016;31:938–946.
http://humrep.oxfordjournals.org/cgi/content/abstract/31/5/938

HUWE1interactswithPCNAtoalleviatereplicationstress
KatherineNChoe,ClaudiaMNicolae,DanielConstantin,YukaImamuraKawasawa,MariaRocioDelgado-Diaz,SubhajyotiDe,RaimundoFreire,VeroniqueAJSmits,andGeorge-LucianMoldovan
EMBORep.,May2016;10.15252/embr.201541685.
http://EMBOr.embopress.org/cgi/content/abstract/embr.201541685v1

PKCαandHMGB1antagoNISTicallycontrolhydrogenperoxide-inducedpoly-ADP-riboseformation
AnneliAndersson,AndrejBluwstein,NitinKumar,FedericoTeloni,JensTraenkle,MichaelBaudis,MatthiasAltmeyer,andMichaelO.Hottiger
NucleicAcidsRes.,May2016;10.1093/nar/gkw442.
http://nar.oxfordjournals.org/cgi/content/abstract/gkw442v1

DisruptionofDNADamage-ResponsebyPropylGallateand9-Aminoacridine
ShunMatsuda,YokoMatsuda,Shin-YaYanagisawa,MasaeIkura,TsuyoshiIkura,andTomonariMatsuda
Toxicol.Sci.,Jun2016;151:224–235.
http://toxsci.oxfordjournals.org/cgi/content/abstract/151/2/224

“AubiquitylationsiteinCockaynesyndromeBrequiredforrepairof
oxidativeDNAdamage,butnotfortranscription-couplednucleotide
excisionrepair”
“MichaelRanes,StefanBoeing,YumingWang,FranziskaWienholz,HervéMenoni,JaneWalker,Vesela
Encheva,ProbirChakravarty,Pierre-OlivierMari,AengusStewart,GiuseppinaGiglia-Mari,AmbrosiusP.
Snijders,WimVermeulen,andJesperQ.Svejstrup”
NucleicAcidsRes.,Jun2016;44:5246–5255.
http://nar.oxfordjournals.org/cgi/content/abstract/44/11/5246

“TriplexstructuresinduceDNAdoublestrandbreaksviareplicationforkcollapseinNERdeficientcells”
“MeetuKaushikTiwari,NneomaAdaku,NatoyaPeart,andFayeA.Rogers”
NucleicAcidsRes.,Jun2016;10.1093/nar/gkw515
http://nar.oxfordjournals.org/cgi/content/abstract/gkw515v1

“DifferencesinquantificationofDNAdouble-strandbreaksassessedby53BP1/H2AXfocusformationassaysandthecometassayinmammaliancellstreatedwithirrADIationandN-acetyl-L-cysteine”
TomomiKurashige,MikaShimamura,andYujiNagayama
JRadiatRes,Jun2016;57:312–317
http://jrr.oxfordjournals.org/cgi/content/abstract/57/3/312

“HUWE1interactswithPCNAtoalleviatereplicationstress”
“KatherineNChoe,ClaudiaMNicolae,DanielConstantin,YukaImamuraKawasawa,MariaRocio
Delgado-Diaz,SubhajyotiDe,RaimundoFreire,VeroniqueAJSmits,andGeorge-LucianMoldovan”
EMBORep.,Jun2016;17:874–886.
http://EMBOr.embopress.org/cgi/content/abstract/17/6/874

“DNADamageResponseandDNARepairinSkeletalMyocytesFroma
MouseModelofSpinalMuscularAtrophy”
SaniyaFayzullinaandLeeJ.Martin
JNeuropatholExpNeurol,Jul2016;10.1093/jnen/nlw064
http://jnen.oxfordjournals.org/cgi/content/abstract/nlw064v1

“OverexpressionofHPV16E6*Altersβ-IntegrinandMitochondrial
DysfunctionPathwaysinCervicalCancerCells”
“WHITNEYEVANS,MARIAFILIPPOVA,VALERYFILIPPOV,SVETLANABASHKIROVA,GUANGYUZHANG,MARKE.REEVES,andPENELOPEDUERKSEN-HUGHES”
CancerGenomicsProteomics,Jul2016;13:259–273
http://cgp.iiarjournals.org/cgi/content/abstract/13/4/259

“AndrogenDeprivationFollowedbyAcuteAndrogenStimulation
SelectivelySensitizesAR-PositiveProstateCancerCellstoIonizing
Radiation”
“MohammadHedayati,MichaelC.Haffner,JonathanB.Coulter,RajuR.Raval,YonggangZhang,Haoming
Zhou,OmarMian,EmmaJ.Knight,NinaRazavi,SusanDalrymple,JohnT.Isaacs,AileenSantos,Russell
Hales,WilliamG.Nelson,SrinivasanYegnasubramanian,andTheodoreL.DeWeese”
Clin.CancerRes.,Jul2016;22:3310–3319
http://clincancerres.aacrjournals.org/cgi/content/abstract/22/13/3310

“NQO1-MediatedTumor-SelectiveLethalityandRadiosensitizationfor
HeadandNeckCancer”
“Long-ShanLi,SrilakshmiReddy,Zhen-HuaLin,ShuangpingLiu,HyunsilPark,StephenG.Chun,WilliamG.
Bornmann,JoelThibodeaux,JingshengYan,GaurabChakrabarti,Xian-JinXie,BaranD.Sumer,DavidA.
Boothman,andJohnS.Yordy”
Mol.CancerTher.,Jul2016;15:1757–1767
http://mct.aacrjournals.org/cgi/content/abstract/15/7/1757

“HOXC10ExpressionSupportstheDevelopmentofChemotherapy
ResistancebyFineTuningDNARepairinBreastCancerCells”
“HelenSadik,PreethiKorangath,NguyenK.Nguyen,BalazsGyorffy,RakeshKumar,Mohammad
Hedayati,WeiWenTeo,SunjuPark,HardikPanday,TeresaGonzalezMunoz,OtiliaMenyhart,NilayShah,RajK.Pandita,JennyC.Chang,TheodoreDeWeese,HowardY.Chang,TejK.Pandita,andSaraswatiSukumar”
CancerRes.,Aug2016;76:4443–4456.
http://cancerres.aacrjournals.org/cgi/content/abstract/76/15/4443

“Apanelofinvitroteststoevaluategenotoxicandmorphological
neoplastictransformationpotentialonBalb/3T3cellsbypristineandremediatedtitaniaandzirconiananoparticles”
“AndreaStoccoro,SebastianoDiBucchianico,ChiaraUboldi,FABIoCoppedè,JessicaPonti,ClaudiaPlacidi,
MagdaBlosi,SimonaOrtelli,AnnaLuisaCosta,andLuciaMigliore”
Mutagenesis,Sep2016;31:511–529.
http://mutage.oxfordjournals.org/cgi/content/abstract/31/5/511

Distribution,quantificationandtoxicityofcinnamaldehydeinelectroniccigaretterefillfluidsandaerosols
RachelZBehar,WentaiLuo,SabrinaCLin,YuhuanWang,JackelynValle,JamesFPankow,andPrueTalbot
Tob.Control,Sep2016;10.1136/tobaccocontrol-2016-053224
http://tobaccocontrol.bmj.com/cgi/content/abstract/tobaccocontrol-2016-053224v1

TriplexstructuresinduceDNAdoublestrandbreaksviareplicationforkcollapseinNERdeficientcells
MeetuKaushikTiwari,NneomaAdaku,NatoyaPeart,andFayeA.Rogers
NucleicAcidsRes.,Sep2016;44:7742–7754
http://nar.oxfordjournals.org/cgi/content/abstract/44/16/7742

“TheMCT4Gene:ANovel,PotentialTargetforTherapyofAdvancedProstateCancer”
“StephenYiuChuenChoi,HuiXue,RebeccaWu,LadanFazli,DongLin,ColinC.Collins,MartinE.Gleave,PeterW.Gout,andYuzhuoWang”
Clin.CancerRes.,Jun2016;22:2721–2733
http://clincancerres.aacrjournals.org/cgi/content/abstract/22/11/2721